Aqp3 | aquaporin 3

GeneMGI:1333777

Physiological systems

19 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region

17 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

1Associated diseases

Expression examined in:46Adult tissues

21Embryo tissues

Phenotypes

Phy. System:



increased circulating alkaline phosphatase level	1 supporting dataset	Aqp3^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	8.14x10^-15
increased blood urea nitrogen level	1 supporting dataset	Aqp3^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	1.86x10^-11
increased lean body mass	1 supporting dataset	Aqp3^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	2.06x10^-5
increased circulating total protein level	1 supporting dataset	Aqp3^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	3.45x10^-8
increased circulating cholesterol level	1 supporting dataset	Aqp3^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	4.39x10^-5
increased circulating HDL cholesterol level	1 supporting dataset	Aqp3^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	1.22x10^-5
increased circulating creatinine level	1 supporting dataset	Aqp3^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	3.19x10^-6
increased circulating serum albumin level	1 supporting dataset	Aqp3^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	1.23x10^-6
increased circulating calcium level	1 supporting dataset	Aqp3^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	9.41x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Aqp3.

Associated images

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Histopathology

There is no histopathology data found for Aqp3.

IMPC related publications

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External links

No external links available for Aqp3.

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*Aqp3^{tm1(EGFP/cre/ERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell mouse
*Aqp3^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Aqp3^{tm213839(pL1L2_GT0_DelLacZ_bsd)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Aqp3^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Aqp3^{tm2b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Aqp3^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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