Arg2 | arginase type II
Physiological systems
22 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Immune system Endocrine/exocrine gland Growth/size/body region Hearing/vestibular/ear Hematopoietic system Behavior/neurological Skeleton Cardiovascular system
14 No significant impact
2 Not tested
Data collections
Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal heart morphology | 2 supporting datasets | Arg2em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| enlarged heart | 1 supporting dataset | Arg2em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| small spleen | 1 supporting dataset | Arg2em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal auditory brainstem response | 1 supporting dataset | Arg2em1(IMPC)Ccpcz | homozygote | Early adult | 1.59x10-7 | ||
| abnormal thymus morphology | 1 supporting dataset | Arg2em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| enlarged thymus | 1 supporting dataset | Arg2em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| kyphosis | 1 supporting dataset | Arg2em1(IMPC)Ccpcz | homozygote | Early adult | 5.36x10-5 | ||
| decreased exploration in new environment | 1 supporting dataset | Arg2em1(IMPC)Ccpcz | homozygote | Early adult | 9.59x10-8 | ||
| abnormal spine curvature | 1 supporting dataset | Arg2em1(IMPC)Ccpcz | homozygote | Early adult | 7.43x10-6 | ||
| lordosis | 1 supporting dataset | Arg2em1(IMPC)Ccpcz | homozygote | Early adult | 1.49x10-6 |
| | | | | | | | | | |
Human diseases caused by Arg2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Arg2.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Arg2em1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Arg2tm89576(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |