Dyrk1b | dual-specificity tyrosine phosphorylation regulated kinase 1b
Physiological systems
19 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Hearing/vestibular/ear Vision/eye Nervous system Hematopoietic system Behavior/neurological Skeleton Mortality/aging
10 No significant impact
5 Not tested
Data collections
Gene metrics:13Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal retina morphology | 1 supporting dataset | Dyrk1btm1b(EUCOMM)Wtsi | heterozygote | Early adult | 4.11x10-5 | ||
| decreased total retina thickness | 2 supporting datasets | Dyrk1btm1b(EUCOMM)Wtsi | heterozygote | Late adult | 1.67x10-13 | ||
| decreased total retina thickness | 2 supporting datasets | Dyrk1btm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.3x10-10 | ||
| decreased lymphocyte cell number | 1 supporting dataset | Dyrk1btm1b(EUCOMM)Wtsi | heterozygote | Early adult | 9.12x10-5 | ||
| decreased startle reflex | 1 supporting dataset | Dyrk1btm1b(EUCOMM)Wtsi | heterozygote | Early adult | 6.32x10-5 | ||
| abnormal retina inner nuclear layer morphology | 2 supporting datasets | Dyrk1btm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.21x10-9 | ||
| decreased locomotor activity | 2 supporting datasets | Dyrk1btm1b(EUCOMM)Wtsi | heterozygote | Late adult | 1.75x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Dyrk1btm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| decreased large unstained cell number | 2 supporting datasets | Dyrk1btm1b(EUCOMM)Wtsi | heterozygote | Early adult | 7.55x10-7 | ||
| abnormal retina outer nuclear layer morphology | 1 supporting dataset | Dyrk1btm1b(EUCOMM)Wtsi | heterozygote | Late adult | 6.25x10-5 |
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Human diseases caused by Dyrk1b mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Dyrk1b.
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| Dyrk1btm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Dyrk1btm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Dyrk1btm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Dyrk1btm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |