Dyrk1b | dual-specificity tyrosine phosphorylation regulated kinase 1b

GeneMGI:1330302Synonyms: Mirk

Physiological systems

19 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hearing/vestibular/ear Vision/eye Nervous system Hematopoietic system Behavior/neurological Skeleton Mortality/aging

10 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal retina morphology	1 supporting dataset	Dyrk1b^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	4.11x10^-5
decreased total retina thickness	2 supporting datasets	Dyrk1b^{tm1b(EUCOMM)Wtsi}	heterozygote	Late adult	1.67x10^-13
decreased total retina thickness	2 supporting datasets	Dyrk1b^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.3x10^-10
decreased lymphocyte cell number	1 supporting dataset	Dyrk1b^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	9.12x10^-5
decreased startle reflex	1 supporting dataset	Dyrk1b^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.32x10^-5
abnormal retina inner nuclear layer morphology	2 supporting datasets	Dyrk1b^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.21x10^-9
decreased locomotor activity	2 supporting datasets	Dyrk1b^{tm1b(EUCOMM)Wtsi}	heterozygote	Late adult	1.75x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Dyrk1b^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased large unstained cell number	2 supporting datasets	Dyrk1b^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	7.55x10^-7
abnormal retina outer nuclear layer morphology	1 supporting dataset	Dyrk1b^{tm1b(EUCOMM)Wtsi}	heterozygote	Late adult	6.25x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dyrk1b.

Associated images

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Histopathology

There is no histopathology data found for Dyrk1b.

IMPC related publications

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External links

No external links available for Dyrk1b.

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*Dyrk1b^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Dyrk1b^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Dyrk1b^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Dyrk1b^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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