Smarcb1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
Physiological systems
20 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Integument Nervous system Mortality/aging
17 No significant impact
4 Not tested
Data collections
Gene metrics:5Significant phenotypes
9Associated diseases
Expression examined in:0Adult tissues
62Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Smarcb1tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Smarcb1tm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * | ||
| abnormal coat appearance | 1 supporting dataset | Smarcb1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.05x10-6 | ||
| decreased prepulse inhibition | 4 supporting datasets | Smarcb1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.14x10-6 | ||
| abnormal skin coloration | 1 supporting dataset | Smarcb1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 9.8x10-12 |
| | | | | | | | | | |
Human diseases caused by Smarcb1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Smarcb1.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Smarcb1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Smarcb1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Smarcb1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |