Grcc10 | gene rich cluster, C10 gene
Physiological systems
20 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Homeostasis/metabolism Mortality/aging
18 No significant impact
4 Not tested
Gene metrics:2Significant phenotypes
2Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Grcc10tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| cyanosis | 1 supporting dataset | Grcc10tm1.1(KOMP)Vlcg | homozygote | E18.5 | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Grcc10 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Grcc10.
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| Grcc10tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Grcc10tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Grcc10tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Grcc10tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Grcc10tm3(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |