Emg1 | EMG1 N1-specific pseudouridine methyltransferase
Physiological systems
20 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Mortality/aging
17 No significant impact
4 Not tested
Data collections
Gene metrics:5Significant phenotypes
2Associated diseases
Expression examined in:50Adult tissues
62Embryo tissues
| decreased total retina thickness | 2 supporting datasets | Emg1tm1.1(KOMP)Wtsi | heterozygote | Early adult | 4.59x10-7 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Emg1tm1.1(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Emg1tm1.1(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| abnormal retina inner nuclear layer morphology | 2 supporting datasets | Emg1tm1.1(KOMP)Wtsi | heterozygote | Early adult | 1.26x10-6 | ||
| decreased circulating aspartate transaminase level | 1 supporting dataset | Emg1tm1.1(KOMP)Wtsi | heterozygote | Early adult | 1.46x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Wholemount images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Wholemount images | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | Wholemount images | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Wholemount images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Wholemount images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | Wholemount images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Emg1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Emg1.
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| Emg1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Emg1tm1(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell mouse |
| Emg1tm1.1(KOMP)Wtsi | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Emg1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |