Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Nervous system Hematopoietic system Behavior/neurological
15 No significant impact
4 Not tested
Data collections
Viability data
Body weight measurements
Embryo imaging data
Body weight measurements
Embryo imaging data
Gene metrics:5Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased prepulse inhibition | 3 supporting datasets | Tnfrsf1btm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.44x10-5 | ||
| increased B cell number | 1 supporting dataset | Tnfrsf1btm1a(EUCOMM)Wtsi | homozygote | Early adult | 9.42x10-5 | ||
| increased circulating total protein level | 1 supporting dataset | Tnfrsf1btm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.42x10-5 | ||
| decreased locomotor activity | 1 supporting dataset | Tnfrsf1btm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.54x10-6 | ||
| decreased T cell number | 1 supporting dataset | Tnfrsf1btm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.88x10-5 |
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Human diseases caused by Tnfrsf1b mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tnfrsf1b.
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| Tnfrsf1btm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Tnfrsf1btm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |