Hipk2 | homeodomain interacting protein kinase 2
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Growth/size/body region Vision/eye Skeleton Craniofacial Cardiovascular system Mortality/aging Renal/urinary system
13 No significant impact
4 Not tested
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| abnormal tooth morphology | 3 supporting datasets | Hipk2tm2b(EUCOMM)Hmgu | homozygote | Early adult | 1.52x10-6 | ||
| abnormal snout morphology | 1 supporting dataset | Hipk2tm2b(EUCOMM)Hmgu | homozygote | Early adult | 4.9x10-5 | ||
| abnormal lens morphology | 1 supporting dataset | Hipk2tm2b(EUCOMM)Hmgu | homozygote | Early adult | 9.54x10-6 | ||
| increased kidney weight | 1 supporting dataset | Hipk2tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 1.85x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Hipk2tm2b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| abnormal maxilla morphology | 1 supporting dataset | Hipk2tm2b(EUCOMM)Hmgu | homozygote | Early adult | 3.08x10-5 | ||
| increased heart weight | 1 supporting dataset | Hipk2tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 4.5x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (4/4) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (4/4) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/4) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (4/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (4/4) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 100% (4/4) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (4/4) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (4/4) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (4/4) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 75% (3/4) | 1.67% (7/419) |
Human diseases caused by Hipk2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Hipk2.
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| Hipk2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Hipk2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Hipk2tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Hipk2tm2b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Hipk2tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |