Knstrn | kinetochore-localized astrin/SPAG5 binding

GeneMGI:1289298Synonyms: 1700025D04Rik, D2Ertd750e

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Hematopoietic system Behavior/neurological

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased erythrocyte cell number	1 supporting dataset	Knstrn^{tm1b(KOMP)Wtsi}	homozygote	Early adult	9.45x10^-15
decreased hematocrit	1 supporting dataset	Knstrn^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.16x10^-5
thrombocytopenia	1 supporting dataset	Knstrn^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.94x10^-8
increased mean corpuscular volume	1 supporting dataset	Knstrn^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.25x10^-39
abnormal seminal vesicle morphology	1 supporting dataset	Knstrn^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased mean corpuscular hemoglobin	1 supporting dataset	Knstrn^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.36x10^-38
tremors	1 supporting dataset	Knstrn^{tm1b(KOMP)Wtsi}	homozygote	Early adult	9.47x10^-6
increased fasting circulating glucose level	1 supporting dataset	Knstrn^{tm1b(KOMP)Wtsi}	homozygote	Early adult	9x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Knstrn.

Associated images

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Histopathology

There is no histopathology data found for Knstrn.

IMPC related publications

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External links

No external links available for Knstrn.

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*Knstrn^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Knstrn^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Knstrn^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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