Knstrn | kinetochore-localized astrin/SPAG5 binding
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Hematopoietic system Behavior/neurological
15 No significant impact
4 Not tested
Data collections
Gene metrics:8Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased erythrocyte cell number | 1 supporting dataset | Knstrntm1b(KOMP)Wtsi | homozygote | Early adult | 9.45x10-15 | ||
| decreased hematocrit | 1 supporting dataset | Knstrntm1b(KOMP)Wtsi | homozygote | Early adult | 1.16x10-5 | ||
| thrombocytopenia | 1 supporting dataset | Knstrntm1b(KOMP)Wtsi | homozygote | Early adult | 2.94x10-8 | ||
| increased mean corpuscular volume | 1 supporting dataset | Knstrntm1b(KOMP)Wtsi | homozygote | Early adult | 5.25x10-39 | ||
| abnormal seminal vesicle morphology | 1 supporting dataset | Knstrntm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Knstrntm1b(KOMP)Wtsi | homozygote | Early adult | 1.36x10-38 | ||
| tremors | 1 supporting dataset | Knstrntm1b(KOMP)Wtsi | homozygote | Early adult | 9.47x10-6 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Knstrntm1b(KOMP)Wtsi | homozygote | Early adult | 9x10-5 |
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Human diseases caused by Knstrn mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Knstrn.
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| Knstrntm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Knstrntm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Knstrntm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |