Setd3 | SET domain containing 3

GeneMGI:1289184Synonyms: D12Ertd771e, 2610305M23Rik, +1 more

Physiological systems

18 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Limbs/digits/tail Nervous system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

8 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:20Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



short tibia	1 supporting dataset	Setd3^{tm1.1(NCOM)Mfgc}	homozygote	Early adult	6.67x10^-10
small testis	1 supporting dataset	Setd3^{tm1.1(NCOM)Mfgc}	homozygote	Early adult	N/A ^*
decreased prepulse inhibition	4 supporting datasets	Setd3^{tm1.1(NCOM)Mfgc}	homozygote	Early adult	1.07x10^-11
decreased body length	1 supporting dataset	Setd3^{tm1.1(NCOM)Mfgc}	homozygote	Early adult	2.33x10^-5
abnormal seminal vesicle morphology	1 supporting dataset	Setd3^{tm1.1(NCOM)Mfgc}	homozygote	Early adult	N/A ^*
increased bone mineral density	1 supporting dataset	Setd3^{tm1.1(NCOM)Mfgc}	homozygote	Early adult	9.76x10^-7
increased leukocyte cell number	1 supporting dataset	Setd3^{tm1.1(NCOM)Mfgc}	homozygote	Early adult	5.47x10^-5
vertebral fusion	1 supporting dataset	Setd3^{tm1.1(NCOM)Mfgc}	homozygote	Early adult	6.83x10^-7
shortened QT interval	1 supporting dataset	Setd3^{tm1.1(NCOM)Mfgc}	homozygote	Early adult	8.5x10^-5
increased bone mineral content	1 supporting dataset	Setd3^{tm1.1(NCOM)Mfgc}	homozygote	Early adult	3.2x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Setd3.

Associated images

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Histopathology

There is no histopathology data found for Setd3.

IMPC related publications

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External links

No external links available for Setd3.

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*Setd3^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell mouse
*Setd3^{tm1.1(NCOM)Mfgc}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse

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