Mpzl2 | myelin protein zero-like 2

GeneMGI:1289160Synonyms: Eva, Eva1

Physiological systems

19 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Pigmentation Integument Adipose tissue Limbs/digits/tail Hearing/vestibular/ear Hematopoietic system Behavior/neurological Skeleton

11 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

2Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



long tibia	1 supporting dataset	Mpzl2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.21x10^-8
abnormal gait	1 supporting dataset	Mpzl2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.91x10^-5
increased total body fat amount	2 supporting datasets	Mpzl2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.5x10^-6
abnormal coat/hair pigmentation	1 supporting dataset	Mpzl2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.76x10^-5
abnormal ear morphology	1 supporting dataset	Mpzl2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.49x10^-5
increased red blood cell distribution width	1 supporting dataset	Mpzl2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.7x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression



adrenal gland	heterozygote	n/a	0% (0/2)	0.7% (4/570)
aorta	heterozygote	n/a	0% (0/2)	0.19% (1/533)
bone	heterozygote	n/a	0% (0/2)	0% (0/394)
brain	heterozygote	n/a	0% (0/2)	0.86% (5/579)
brainstem	heterozygote	n/a	0% (0/2)	0.41% (2/490)
brown adipose tissue	heterozygote	n/a	0% (0/2)	0% (0/588)
cartilage tissue	heterozygote	n/a	0% (0/2)	0.22% (1/454)
cerebellum	heterozygote	n/a	0% (0/2)	0.56% (3/532)
cerebral cortex	heterozygote	n/a	0% (0/2)	0.41% (2/491)
esophagus	heterozygote	n/a	0% (0/2)	1.67% (7/419)

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Associated images

6 images

Adult LacZ

LacZ Images Wholemount

116 images

Echo

M-Mode Images

8 images

Embryo LacZ

LacZ images wholemount

4 images

X-ray

XRay Images Skull Dorso Ventral Orientation

4 images

X-ray

XRay Images Whole Body Dorso Ventral

3 images

X-ray

XRay Images Whole Body Lateral Orientation

Histopathology

There is no histopathology data found for Mpzl2.

IMPC related publications

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External links

No external links available for Mpzl2.

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*Mpzl2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Mpzl2^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Mpzl2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

My Genes

Mpzl2 | myelin protein zero-like 2

Physiological systems

8 Significantly impacted by the knock-out

11 No significant impact

5 Not tested

Data collections

Phenotypes

lacZ Expression

Associated images

Adult LacZ

Echo

Embryo LacZ

X-ray

X-ray

X-ray

Histopathology

IMPC related publications

External links

Order Mouse and ES Cells

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Access Data Release 22.1 Data