Snca | synuclein, alpha
Physiological systems
19 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system
13 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
6Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased mean platelet volume | 1 supporting dataset | Sncaem1(IMPC)H | homozygote | Late adult | 2.5x10-5 | ||
| increased spleen weight | 1 supporting dataset | Sncaem1(IMPC)H | homozygote | Late adult | 1.42x10-20 | ||
| increased circulating creatinine level | 1 supporting dataset | Sncaem1(IMPC)H | homozygote | Late adult | 9.85x10-9 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Sncaem1(IMPC)H | homozygote | Early adult | 6.46x10-5 | ||
| abnormal locomotor behavior | 1 supporting dataset | Sncaem1(IMPC)H | homozygote | Early adult | 4.06x10-5 | ||
| prolonged PR interval | 1 supporting dataset | Sncaem1(IMPC)H | homozygote | Late adult | 9.8x10-5 | ||
| increased circulating amylase level | 1 supporting dataset | Sncaem1(IMPC)H | homozygote | Late adult | 1.59x10-5 |
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Human diseases caused by Snca mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Snca.
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| Sncaem1(IMPC)H | Exon Deletion | | mouse |
| Sncaem2(IMPC)H | Exon Deletion | | mouse |
| Sncatm364452(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |