Birc6 | baculoviral IAP repeat-containing 6
Physiological systems
23 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Vision/eye Behavior/neurological Mortality/aging Cardiovascular system
17 No significant impact
1 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal heart morphology | 1 supporting dataset | Birc6em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| enlarged heart | 1 supporting dataset | Birc6em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| increased circulating creatine kinase level | 1 supporting dataset | Birc6em1(IMPC)Ccpcz | heterozygote | Early adult | 4.38x10-7 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Birc6em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| no spontaneous movement | 1 supporting dataset | Birc6em1(IMPC)Ccpcz | homozygote | E18.5 | N/A * | ||
| abnormal retina morphology | 1 supporting dataset | Birc6em1(IMPC)Ccpcz | heterozygote | Early adult | 4.66x10-8 | ||
| edema | 1 supporting dataset | Birc6em1(IMPC)Ccpcz | homozygote | E15.5 | N/A * |
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Human diseases caused by Birc6 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Birc6.
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| Birc6em1(IMPC)Ccpcz | Exon Deletion | | mouse |