Mmp16 | matrix metallopeptidase 16

GeneMGI:1276107Synonyms: MT3-MMP, Membrane type 3-MMP

Physiological systems

17 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Vision/eye Behavior/neurological

15 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



hyperactivity	8 supporting datasets	Mmp16^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.28x10^-13
abnormal eye morphology	1 supporting dataset	Mmp16^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
hypoalgesia	1 supporting dataset	Mmp16^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.21x10^-6 ^**
decreased anxiety-related response	1 supporting dataset	Mmp16^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.4x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

** Significant with a threshold of 1x10^-3, check the Pain Sensitivity page for more information.

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* This parameter was manually assessed for significance.

** Significant with a threshold of 1x10^-3, check the Pain Sensitivity page for more information.

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lacZ Expression



adrenal gland	heterozygote	n/a	100% (2/2)	0.7% (4/570)
aorta	heterozygote	n/a	100% (2/2)	0.19% (1/533)
bone	heterozygote	n/a	100% (2/2)	0% (0/394)
brain	heterozygote	n/a	100% (2/2)	0.86% (5/579)
brainstem	heterozygote	n/a	100% (2/2)	0.41% (2/490)
brown adipose tissue	heterozygote	n/a	0% (0/2)	0% (0/588)
cartilage tissue	heterozygote	n/a	100% (2/2)	0.22% (1/454)
cerebellum	heterozygote	n/a	100% (2/2)	0.56% (3/532)
cerebral cortex	heterozygote	n/a	100% (2/2)	0.41% (2/491)
esophagus	heterozygote	n/a	100% (2/2)	1.67% (7/419)

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Associated images

17 images

Adult LacZ

LacZ Images Wholemount

Download files

Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

28 images

Echo

M-Mode Images

4 images

Embryo LacZ

LacZ images wholemount

Human diseases caused by Mmp16 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.



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Histopathology

There is no histopathology data found for Mmp16.

IMPC related publications

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External links

No external links available for Mmp16.

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*Mmp16^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Mmp16^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Mmp16^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Mmp16^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

My Genes

Mmp16 | matrix metallopeptidase 16

Physiological systems

2 Significantly impacted by the knock-out

15 No significant impact

7 Not tested

Data collections

Phenotypes

lacZ Expression

Associated images

Adult LacZ

Auditory Brain Stem Response

Echo

Embryo LacZ

Human diseases caused by Mmp16 mutations

Histopathology

IMPC related publications

External links

Order Mouse and ES Cells

The IMPC Newsletter

Access Data Release 22.1 Data