Prep | prolyl endopeptidase
Physiological systems
19 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Behavior/neurological Mortality/aging
16 No significant impact
5 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
21Embryo tissues
| decreased thigmotaxis | 2 supporting datasets | Preptm1b(KOMP)Wtsi | heterozygote | Early adult | 1.86x10-5 | ||
| increased circulating sodium level | 1 supporting dataset | Preptm1b(KOMP)Wtsi | heterozygote | Early adult | 1.86x10-5 | ||
| increased circulating potassium level | 1 supporting dataset | Preptm1b(KOMP)Wtsi | heterozygote | Early adult | 2.65x10-5 | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Preptm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
| decreased circulating free fatty acids level | 1 supporting dataset | Preptm1b(KOMP)Wtsi | heterozygote | Early adult | 3.65x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Preptm1b(KOMP)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Prep mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Prep.
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| Preptm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Preptm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Preptm96475(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |