Axin2 | axin 2

GeneMGI:1270862Synonyms: Axil, Conductin

Physiological systems

20 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Integument Embryo Growth/size/body region Digestive/alimentary Limbs/digits/tail Vision/eye Behavior/neurological Craniofacial Mortality/aging

11 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

5Associated diseases

Expression examined in:51Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal facial morphology	2 supporting datasets	Axin2^{tm1b(KOMP)Wtsi}	homozygote	E18.5	N/A ^*
abnormal body wall morphology	1 supporting dataset	Axin2^{tm1b(KOMP)Wtsi}	homozygote	E18.5	N/A ^*
abnormal eyelid fusion	1 supporting dataset	Axin2^{tm1b(KOMP)Wtsi}	homozygote	E18.5	N/A ^*
microphthalmia	1 supporting dataset	Axin2^{tm1b(KOMP)Wtsi}	homozygote	E18.5	N/A ^*
abnormal limb morphology	1 supporting dataset	Axin2^{tm1b(KOMP)Wtsi}	homozygote	E18.5	N/A ^*
abnormal head shape	1 supporting dataset	Axin2^{tm1b(KOMP)Wtsi}	homozygote	E18.5	N/A ^*
polydactyly	1 supporting dataset	Axin2^{tm1b(KOMP)Wtsi}	homozygote	E18.5	N/A ^*
unresponsive to tactile stimuli	1 supporting dataset	Axin2^{tm1b(KOMP)Wtsi}	homozygote	E18.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Axin2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
unresponsive to tactile stimuli	1 supporting dataset	Axin2^{tm1b(KOMP)Wtsi}	heterozygote	E18.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Axin2.

Associated images

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Histopathology

There is no histopathology data found for Axin2.

IMPC related publications

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External links

No external links available for Axin2.

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*Axin2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Axin2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Axin2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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