Slc6a2 | solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging
14 No significant impact
5 Not tested
Gene metrics:5Significant phenotypes
2Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| small heart | 1 supporting dataset | Slc6a2tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| abnormal gait | 1 supporting dataset | Slc6a2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.24x10-7 | ||
| decreased hemoglobin content | 1 supporting dataset | Slc6a2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 4.7x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Slc6a2tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| impaired glucose tolerance | 1 supporting dataset | Slc6a2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.81x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Slc6a2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Slc6a2.
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| Slc6a2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Slc6a2tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Slc6a2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |