Tcf21 | transcription factor 21
Physiological systems
22 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Embryo Growth/size/body region Vision/eye Hematopoietic system Mortality/aging Cardiovascular system Renal/urinary system
11 No significant impact
2 Not tested
Data collections
Gene metrics:18Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| anophthalmia | 1 supporting dataset | Tcf21em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Tcf21em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal ovary morphology | 1 supporting dataset | Tcf21em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| enlarged testis | 1 supporting dataset | Tcf21em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal kidney morphology | 1 supporting dataset | Tcf21em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal spleen morphology | 1 supporting dataset | Tcf21em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| small spleen | 1 supporting dataset | Tcf21em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Tcf21em1(IMPC)Mbp | heterozygote | E15.5 | N/A * | ||
| abnormal blood vessel morphology | 1 supporting dataset | Tcf21em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| abnormal placenta vasculature | 1 supporting dataset | Tcf21em1(IMPC)Mbp | homozygote | E15.5 | N/A * |
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Human diseases caused by Tcf21 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Tcf21.
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| Tcf21em1(IMPC)Mbp | Intra-exon deletion | | mouse |
| Tcf21tm417684(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |