Pknox1 | Pbx/knotted 1 homeobox

GeneMGI:1201409Synonyms: PREP1, D17Wsu76e

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Immune system Hematopoietic system Mortality/aging Renal/urinary system

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased IgG1 level	1 supporting dataset	Pknox1^{Gt(EUCJ0079d10)Hmgu}	heterozygote	Early adult	9.98x10^-5
decreased B cell number	1 supporting dataset	Pknox1^{Gt(EUCJ0079d10)Hmgu}	heterozygote	Early adult	4.72x10^-5
decreased mature B cell number	1 supporting dataset	Pknox1^{Gt(EUCJ0079d10)Hmgu}	heterozygote	Early adult	6.01x10^-8
abnormal urination	1 supporting dataset	Pknox1^{Gt(EUCJ0079d10)Hmgu}	heterozygote	Early adult	3.65x10^-5
decreased mean corpuscular hemoglobin concentration	1 supporting dataset	Pknox1^{Gt(EUCJ0079d10)Hmgu}	heterozygote	Early adult	2.95x10^-6
decreased T cell number	1 supporting dataset	Pknox1^{Gt(EUCJ0079d10)Hmgu}	heterozygote	Early adult	6.13x10^-5
decreased hemoglobin content	1 supporting dataset	Pknox1^{Gt(EUCJ0079d10)Hmgu}	heterozygote	Early adult	3.43x10^-8
preweaning lethality, complete penetrance	1 supporting dataset	Pknox1^{Gt(EUCJ0079d10)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pknox1.

Associated images

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Histopathology

There is no histopathology data found for Pknox1.

IMPC related publications

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External links

No external links available for Pknox1.

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*Pknox1^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Pknox1^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell
*Pknox1^{tm2a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Pknox1^{tm2e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell

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