Limk2 | LIM domain kinase 2

GeneMGI:1197517Synonyms: A930024P04Rik, LIM kinase 2, +3 more

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Growth/size/body region Limbs/digits/tail Hematopoietic system Behavior/neurological Skeleton Mortality/aging

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased startle reflex	5 supporting datasets	Limk2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.52x10^-14
preweaning lethality, incomplete penetrance	1 supporting dataset	Limk2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased body length	1 supporting dataset	Limk2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.83x10^-5
increased mean corpuscular hemoglobin concentration	1 supporting dataset	Limk2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.71x10^-5
long tibia	1 supporting dataset	Limk2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	6.67x10^-5
abnormal locomotor activation	1 supporting dataset	Limk2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	5.01x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Limk2.

Associated images

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Histopathology

There is no histopathology data found for Limk2.

IMPC related publications

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External links

No external links available for Limk2.

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*Limk2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse

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