Fubp1 | far upstream element (FUSE) binding protein 1
Physiological systems
21 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Immune system Integument Vision/eye Behavior/neurological Mortality/aging
16 No significant impact
3 Not tested
Data collections
Gene metrics:11Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased anxiety-related response | 1 supporting dataset | Fubp1em1(IMPC)Mbp | heterozygote | Early adult | 4.81x10-5 | ||
| decreased locomotor activity | 1 supporting dataset | Fubp1em1(IMPC)Mbp | heterozygote | Early adult | 3.43x10-21 | ||
| no spontaneous movement | 1 supporting dataset | Fubp1em1(IMPC)Mbp | heterozygote | E18.5 | N/A * | ||
| abnormal behavior | 1 supporting dataset | Fubp1em1(IMPC)Mbp | heterozygote | Early adult | 4.2x10-8 | ||
| abnormal retina morphology | 1 supporting dataset | Fubp1em1(IMPC)Mbp | heterozygote | Early adult | 5.3x10-5 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Fubp1em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| decreased thigmotaxis | 2 supporting datasets | Fubp1em1(IMPC)Mbp | heterozygote | Early adult | 3.69x10-8 | ||
| abnormal skin morphology | 1 supporting dataset | Fubp1em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| enlarged lymph nodes | 1 supporting dataset | Fubp1em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal lymph node morphology | 1 supporting dataset | Fubp1em1(IMPC)Mbp | heterozygote | Early adult | N/A * |
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Human diseases caused by Fubp1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Fubp1.
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| Fubp1em1(IMPC)Mbp | Exon Deletion | | mouse |
| Fubp1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |