Prag1 | PEAK1 related kinase activating pseudokinase 1

GeneMGI:1196223Synonyms: NACK, D8Ertd82e

Physiological systems

17 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Homeostasis/metabolism Nervous system

15 No significant impact

7 Not tested

Gene metrics:2Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased fasting circulating glucose level1 supporting datasetPrag1em2(IMPC)TcphomozygoteEarly adult1.04x10-5 
decreased prepulse inhibition1 supporting datasetPrag1em2(IMPC)TcphomozygoteEarly adult6.13x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Human diseases caused by Prag1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.






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Histopathology

IMPC related publications

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Prag1em2(IMPC)TcpIntra-exon deletionmouse
Prag1tm1a(KOMP)MbpKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Prag1tm1e(KOMP)MbpTargeted, non-conditional alleleES Cell
Prag1tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Prag1tm41666(L1L2_gt0)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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