Kcnj10 | potassium inwardly-rectifying channel, subfamily J, member 10
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Immune system Hematopoietic system Behavior/neurological Mortality/aging
15 No significant impact
5 Not tested
Gene metrics:6Significant phenotypes
4Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues
| tremors | 1 supporting dataset | Kcnj10tm1b(KOMP)Wtsi | heterozygote | Early adult | 9.22x10-5 | ||
| decreased exploration in new environment | 1 supporting dataset | Kcnj10tm1b(KOMP)Wtsi | heterozygote | Early adult | 7.49x10-5 | ||
| increased startle reflex | 1 supporting dataset | Kcnj10tm1b(KOMP)Wtsi | heterozygote | Early adult | 4.76x10-9 | ||
| decreased basophil cell number | 1 supporting dataset | Kcnj10tm1b(KOMP)Wtsi | heterozygote | Early adult | 6.14x10-5 | ||
| decreased mean platelet volume | 1 supporting dataset | Kcnj10tm1b(KOMP)Wtsi | heterozygote | Early adult | 6.53x10-26 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Kcnj10tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 50% (1/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Kcnj10 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Kcnj10.
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| Kcnj10tm1(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Kcnj10tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Kcnj10tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Kcnj10tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |