Npepps | aminopeptidase puromycin sensitive
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Adipose tissue Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Craniofacial
13 No significant impact
4 Not tested
Data collections
Gene metrics:14Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased total retina thickness | 2 supporting datasets | Npeppsem1(IMPC)Hmgu | homozygote | Early adult | 8.31x10-46 | ||
| decreased bone mineral content | 2 supporting datasets | Npeppsem1(IMPC)Hmgu | homozygote | Early adult | 1.82x10-11 | ||
| absent teeth | 1 supporting dataset | Npeppsem1(IMPC)Hmgu | homozygote | Early adult | 3.02x10-5 | ||
| increased grip strength | 2 supporting datasets | Npeppsem1(IMPC)Hmgu | homozygote | Early adult | 8.7x10-9 | ||
| abnormal retina morphology | 1 supporting dataset | Npeppsem1(IMPC)Hmgu | homozygote | Early adult | 1.17x10-19 | ||
| decreased hemoglobin content | 1 supporting dataset | Npeppsem1(IMPC)Hmgu | homozygote | Early adult | 3.26x10-5 | ||
| abnormal tooth morphology | 2 supporting datasets | Npeppsem1(IMPC)Hmgu | homozygote | Early adult | 2.84x10-20 | ||
| decreased locomotor activity | 5 supporting datasets | Npeppsem1(IMPC)Hmgu | homozygote | Early adult | 2.44x10-6 | ||
| decreased vertical activity | 1 supporting dataset | Npeppsem1(IMPC)Hmgu | homozygote | Early adult | 6.16x10-8 | ||
| decreased erythrocyte cell number | 1 supporting dataset | Npeppsem1(IMPC)Hmgu | homozygote | Early adult | 4.68x10-5 |
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Human diseases caused by Npepps mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Npepps.
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| Npeppsem1(IMPC)Hmgu | Exon Deletion | | mouse |
| Npeppstm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Npeppstm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Npeppstm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |