Pitx3 | paired-like homeodomain transcription factor 3
Physiological systems
21 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Vision/eye Behavior/neurological Cardiovascular system
16 No significant impact
3 Not tested
Data collections
Gene metrics:17Significant phenotypes
4Associated diseases
Expression examined in:48Adult tissues
53Embryo tissues
| decreased vertical activity | 1 supporting dataset | Pitx3tm1.1(KOMP)Vlcg | homozygote | Early adult | 5.87x10-7 | ||
| increased coping response | 1 supporting dataset | Pitx3tm1.1(KOMP)Vlcg | homozygote | Early adult | 7.94x10-9 | ||
| abnormal sleep behavior | 7 supporting datasets | Pitx3tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.06x10-32 | ||
| decreased locomotor activity | 1 supporting dataset | Pitx3eyl | homozygote | Early adult | 5.09x10-5 | ||
| hyperactivity | 7 supporting datasets | Pitx3tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.35x10-28 | ||
| decreased circulating free fatty acids level | 1 supporting dataset | Pitx3tm1.1(KOMP)Vlcg | homozygote | Early adult | 3.97x10-5 | ||
| increased grip strength | 1 supporting dataset | Pitx3tm1.1(KOMP)Vlcg | homozygote | Early adult | 4.16x10-5 | ||
| abnormal motor coordination/balance | 1 supporting dataset | Pitx3tm1.1(KOMP)Vlcg | homozygote | Early adult | 6.97x10-5 | ||
| decreased body weight | 4 supporting datasets | Pitx3eyl | homozygote | Early adult | 2.12x10-6 | ||
| decreased vertical activity | 1 supporting dataset | Pitx3eyl | homozygote | Early adult | 4.05x10-8 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Pitx3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Pitx3.
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