Rhpn1 | rhophilin, Rho GTPase binding protein 1

GeneMGI:1098783Synonyms: Rhophilin, Grbp

Physiological systems

21 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system

15 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



hyperactivity	2 supporting datasets	Rhpn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.33x10^-6
abnormal kidney morphology	1 supporting dataset	Rhpn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased mean platelet volume	1 supporting dataset	Rhpn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.19x10^-5
decreased erythrocyte cell number	1 supporting dataset	Rhpn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.5x10^-5
decreased circulating total protein level	1 supporting dataset	Rhpn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	8.26x10^-5
decreased circulating serum albumin level	1 supporting dataset	Rhpn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.44x10^-6
abnormal heart morphology	1 supporting dataset	Rhpn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased heart weight	2 supporting datasets	Rhpn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.03x10^-8
increased circulating HDL cholesterol level	1 supporting dataset	Rhpn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.01x10^-5
enlarged heart	1 supporting dataset	Rhpn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rhpn1.

Associated images

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Histopathology

There is no histopathology data found for Rhpn1.

IMPC related publications

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External links

No external links available for Rhpn1.

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*Rhpn1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Rhpn1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Rhpn1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Rhpn1^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Rhpn1^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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