Tmem222 | transmembrane protein 222
Physiological systems
17 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Nervous system Vision/eye Behavior/neurological Mortality/aging
13 No significant impact
7 Not tested
Data collections
Gene metrics:3Significant phenotypes
2Associated diseases
Expression examined in:49Adult tissues
50Embryo tissues
| impaired pupillary reflex | 1 supporting dataset | Tmem222tm1b(KOMP)Mbp | heterozygote | Early adult | 7.29x10-7 | ||
| decreased prepulse inhibition | 3 supporting datasets | Tmem222tm1b(KOMP)Mbp | heterozygote | Early adult | 1.18x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Tmem222tm1b(KOMP)Mbp | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| bone marrow | heterozygote | Section images | 100% (2/2) | 0% (0/22) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
Human diseases caused by Tmem222 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tmem222.
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| Tmem222tm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Tmem222tm1b(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Tmem222tm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |