Degs1 | delta 4-desaturase, sphingolipid 1
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Cardiovascular system Mortality/aging
15 No significant impact
5 Not tested
Data collections
Gene metrics:4Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Degs1em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal blood vessel morphology | 1 supporting dataset | Degs1em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| edema | 1 supporting dataset | Degs1em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| abnormal eye morphology | 1 supporting dataset | Degs1em1(IMPC)Mbp | heterozygote | Early adult | N/A * |
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Human diseases caused by Degs1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Degs1.
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| Degs1em1(IMPC)Mbp | Exon Deletion | | mouse |
| Degs1tm109219(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |