Car4 | carbonic anhydrase 4
Physiological systems
18 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Behavior/neurological Mortality/aging
15 No significant impact
6 Not tested
Data collections
Gene metrics:3Significant phenotypes
1Associated diseases
Expression examined in:70Adult tissues
0Embryo tissues
| decreased grip strength | 2 supporting datasets | Car4tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.72x10-6 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Car4tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased circulating calcium level | 1 supporting dataset | Car4tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 7.91x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
External links
No external links available for Car4.
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| Car4tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Car4tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Car4tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Car4tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |