Fgf15 | fibroblast growth factor 15

GeneMGI:1096383Synonyms: FGF19

Physiological systems

22 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Nervous system Mortality/aging Cardiovascular system

16 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:41Adult tissues

29Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal brain morphology	1 supporting dataset	Fgf15^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Fgf15^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
edema	1 supporting dataset	Fgf15^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
hydrocephaly	1 supporting dataset	Fgf15^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
abnormal heart morphology	1 supporting dataset	Fgf15^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
abnormal embryo size	1 supporting dataset	Fgf15^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
abnormal placenta size	1 supporting dataset	Fgf15^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
abnormal embryo size	1 supporting dataset	Fgf15^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fgf15.

Associated images

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Histopathology

There is no histopathology data found for Fgf15.

IMPC related publications

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External links

No external links available for Fgf15.

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*Fgf15^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Fgf15^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Fgf15^{tm213553(L1L2_Bact_P)}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector

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