Ackr3 | atypical chemokine receptor 3
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Vision/eye Hematopoietic system Behavior/neurological Mortality/aging
15 No significant impact
5 Not tested
Data collections
Gene metrics:5Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased total retina thickness | 2 supporting datasets | Ackr3tm2b(EUCOMM)Wtsi | heterozygote | Early adult | 2.16x10-5 | ||
| decreased grip strength | 2 supporting datasets | Ackr3tm2b(EUCOMM)Wtsi | heterozygote | Early adult | 2.09x10-6 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Ackr3tm2b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased mean corpuscular hemoglobin concentration | 1 supporting dataset | Ackr3tm2b(EUCOMM)Wtsi | heterozygote | Early adult | 1.6x10-5 | ||
| tremors | 1 supporting dataset | Ackr3tm2b(EUCOMM)Wtsi | heterozygote | Early adult | 7.93x10-5 |
| | | | | | | | | | |
Human diseases caused by Ackr3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ackr3.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Ackr3tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Ackr3tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ackr3tm2b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ackr3tm2e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |