Trpc1 | transient receptor potential cation channel, subfamily C, member 1
Physiological systems
16 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Behavior/neurological
11 No significant impact
8 Not tested
Data collections
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased exploration in new environment | 1 supporting dataset | Trpc1em1(IMPC)H | homozygote | Early adult | 1.11x10-5 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Trpc1em1(IMPC)H | homozygote | Early adult | 6.05x10-6 | ||
| increased spleen weight | 1 supporting dataset | Trpc1em1(IMPC)H | homozygote | Early adult | 2.07x10-9 |
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Human diseases caused by Trpc1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Trpc1.
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| Trpc1em1(IMPC)H | Exon Deletion | | mouse |
| Trpc1em2(IMPC)H | Exon Deletion | | mouse |
| Trpc1tm1(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Trpc1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Trpc1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |