Esr2 | estrogen receptor 2 (beta)

GeneMGI:109392Synonyms: ERbeta, Estrb, +2 more

Physiological systems

17 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system Skeleton Cardiovascular system

10 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased lean body mass	2 supporting datasets	Esr2^{em1(IMPC)Marc}	homozygote	Early adult	3.31x10^-11
increased total body fat amount	2 supporting datasets	Esr2^{em1(IMPC)Marc}	homozygote	Early adult	1.33x10^-11
decreased bone mineral density	1 supporting dataset	Esr2^{em1(IMPC)Marc}	homozygote	Early adult	3.78x10^-7
decreased lymphocyte cell number	1 supporting dataset	Esr2^{em1(IMPC)Marc}	homozygote	Early adult	2.01x10^-6
decreased leukocyte cell number	1 supporting dataset	Esr2^{em1(IMPC)Marc}	homozygote	Early adult	2.14x10^-5
decreased bone mineral content	2 supporting datasets	Esr2^{em1(IMPC)Marc}	homozygote	Early adult	3.41x10^-8
thin ventricular wall	1 supporting dataset	Esr2^{em1(IMPC)Marc}	homozygote	Early adult	1.87x10^-5
increased circulating serum albumin level	1 supporting dataset	Esr2^{em1(IMPC)Marc}	homozygote	Early adult	2.99x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Esr2.

Associated images

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Histopathology

There is no histopathology data found for Esr2.

IMPC related publications

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External links

No external links available for Esr2.

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*Esr2^{em1(IMPC)Marc}*	Deletion	‌	mouse
*Esr2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Esr2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Esr2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Esr2^{tm40116(L1L2_gt2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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