Bnip2 | BCL2/adenovirus E1B interacting protein 2
Physiological systems
18 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Limbs/digits/tail Hematopoietic system Behavior/neurological Skeleton Craniofacial
11 No significant impact
6 Not tested
Data collections
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| abnormal incisor color | 1 supporting dataset | Bnip2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.23x10-17 | ||
| abnormal femur morphology | 1 supporting dataset | Bnip2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.28x10-6 | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Bnip2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.49x10-9 | ||
| increased grip strength | 1 supporting dataset | Bnip2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.79x10-5 | ||
| abnormal cranium morphology | 1 supporting dataset | Bnip2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.4x10-5 | ||
| increased lean body mass | 1 supporting dataset | Bnip2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.44x10-5 | ||
| abnormal tibia morphology | 1 supporting dataset | Bnip2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.26x10-6 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Bnip2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.66x10-7 | ||
| decreased erythrocyte cell number | 1 supporting dataset | Bnip2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.61x10-5 |
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| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 100% (2/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Bnip2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Bnip2.
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| Bnip2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Bnip2tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Bnip2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |