Mapkapk2 | MAP kinase-activated protein kinase 2

GeneMGI:109298Synonyms: MAPKAP kinase 2, MK2, +1 more

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Nervous system Vision/eye Hematopoietic system Skeleton

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased large unstained cell number	2 supporting datasets	Mapkapk2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.41x10^-6
abnormal clavicle morphology	1 supporting dataset	Mapkapk2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.25x10^-5
increased circulating glucose level	1 supporting dataset	Mapkapk2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.08x10^-6
abnormal joint morphology	1 supporting dataset	Mapkapk2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.08x10^-5
abnormal optic disk morphology	1 supporting dataset	Mapkapk2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.03x10^-6
increased eosinophil cell number	1 supporting dataset	Mapkapk2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.14x10^-5
increased leukocyte cell number	1 supporting dataset	Mapkapk2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.2x10^-5
abnormal bone structure	1 supporting dataset	Mapkapk2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.61x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Mapkapk2.

Associated images

Loading...

Histopathology

There is no histopathology data found for Mapkapk2.

IMPC related publications

Loading...

External links

No external links available for Mapkapk2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Mapkapk2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Mapkapk2^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Mapkapk2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

My Genes