Nnt | nicotinamide nucleotide transhydrogenase
Physiological systems
19 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Homeostasis/metabolism Behavior/neurological
17 No significant impact
5 Not tested
Data collections
Gene metrics:3Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased circulating glucose level | 1 supporting dataset | Nntem1(IMPC)H | homozygote | Early adult | 4.81x10-7 | ||
| abnormal gait | 1 supporting dataset | Nntem1(IMPC)H | homozygote | Early adult | 1.31x10-7 | ||
| increased circulating cholesterol level | 1 supporting dataset | Nntem1(IMPC)H | homozygote | Early adult | 9.1x10-5 |
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Human diseases caused by Nnt mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Nnt.
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| Nntem1(IMPC)H | Exon Deletion | | mouse |
| Nnttm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Nnttm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Nnttm41840(L1L2_gt1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |