Spin1 | spindlin 1
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Nervous system Vision/eye Behavior/neurological Mortality/aging
14 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:49Adult tissues
50Embryo tissues
| increased vertical activity | 1 supporting dataset | Spin1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 4.34x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Spin1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| abnormal optic disk morphology | 1 supporting dataset | Spin1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 4.2x10-7 | ||
| hyperactivity | 5 supporting datasets | Spin1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 1.57x10-6 | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Spin1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 3.1x10-6 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Spin1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 7.09x10-7 | ||
| increased startle reflex | 1 supporting dataset | Spin1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 8.9x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| bone marrow | heterozygote | Section images | 100% (2/2) | 0% (0/22) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
Human diseases caused by Spin1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Spin1.
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| Spin1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Spin1tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Spin1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Spin1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |