Ptpn18 | protein tyrosine phosphatase, non-receptor type 18
Physiological systems
17 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Immune system Vision/eye Hematopoietic system Mortality/aging Cardiovascular system
12 No significant impact
7 Not tested
Data collections
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| persistence of hyaloid vascular system | 1 supporting dataset | Ptpn18em1(IMPC)J | heterozygote | Early adult | 5.94x10-8 | ||
| decreased erythrocyte cell number | 1 supporting dataset | Ptpn18em1(IMPC)J | heterozygote | Early adult | 4.92x10-5 | ||
| prolonged RR interval | 1 supporting dataset | Ptpn18em1(IMPC)J | homozygote | Early adult | 3.34x10-5 | ||
| abnormal placement of pupils | 1 supporting dataset | Ptpn18em1(IMPC)J | heterozygote | Early adult | 7.9x10-5 | ||
| cataract | 1 supporting dataset | Ptpn18em1(IMPC)J | heterozygote | Early adult | 4.47x10-6 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Ptpn18em1(IMPC)J | homozygote | Early adult | N/A * | ||
| increased leukocyte cell number | 1 supporting dataset | Ptpn18em1(IMPC)J | homozygote | Early adult | 6.15x10-5 | ||
| decreased heart rate | 1 supporting dataset | Ptpn18em1(IMPC)J | homozygote | Early adult | 7.96x10-6 |
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Human diseases caused by Ptpn18 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ptpn18.
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| Ptpn18em1(IMPC)J | Exon Deletion | | mouse |
| Ptpn18tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Ptpn18tm51109(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |