Apbb2 | amyloid beta precursor protein binding family B member 2
Physiological systems
23 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Integument Embryo Growth/size/body region Nervous system Vision/eye Respiratory system Cardiovascular system Mortality/aging
14 No significant impact
1 Not tested
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
81Embryo tissues
| spina bifida | 1 supporting dataset | Apbb2tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| hemorrhage | 1 supporting dataset | Apbb2tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| hemorrhage | 1 supporting dataset | Apbb2tm1.1(KOMP)Vlcg | heterozygote | E15.5 | N/A * | ||
| abnormal eye morphology | 1 supporting dataset | Apbb2tm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * | ||
| spina bifida | 1 supporting dataset | Apbb2tm1.1(KOMP)Vlcg | heterozygote | E15.5 | N/A * | ||
| preweaning lethality, incomplete penetrance | 2 supporting datasets | Apbb2tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Apbb2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 2.03x10-7 | ||
| increased lung weight | 1 supporting dataset | Apbb2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 1.71x10-5 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Apbb2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 2.48x10-8 | ||
| abnormal skin morphology | 1 supporting dataset | Apbb2tm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 50% (1/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/1) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
Human diseases caused by Apbb2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Apbb2.
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| Apbb2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Apbb2tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Apbb2tm448183(L1L2_GT1_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |