Epha6 | Eph receptor A6
Physiological systems
21 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Reproductive system Immune system Integument Growth/size/body region Liver/biliary system Hematopoietic system Renal/urinary system
14 No significant impact
3 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| abnormal liver morphology | 1 supporting dataset | Epha6tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| enlarged liver | 1 supporting dataset | Epha6tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal epididymis morphology | 1 supporting dataset | Epha6tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| enlarged epididymis | 1 supporting dataset | Epha6tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | Epha6tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal spleen morphology | 1 supporting dataset | Epha6tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal kidney morphology | 1 supporting dataset | Epha6tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/1) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/1) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/1) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/1) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/1) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/1) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/1) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/1) | 0.56% (3/532) |
Human diseases caused by Epha6 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Epha6.
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| Epha6tm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Epha6tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Epha6tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Epha6tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |