Gp1bb | glycoprotein Ib, beta polypeptide
GeneMGI:107852
Physiological systems
21 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Reproductive system Endocrine/exocrine gland Hematopoietic system
18 No significant impact
3 Not tested
Data collections
Gene metrics:7Significant phenotypes
5Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| thrombocytopenia | 1 supporting dataset | Gp1bbtm1.1(KOMP)Vlcg | homozygote | Early adult | 5.38x10-11 | ||
| abnormal uterus morphology | 1 supporting dataset | Gp1bbtm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| increased mean corpuscular volume | 1 supporting dataset | Gp1bbtm1.1(KOMP)Vlcg | homozygote | Early adult | 5.26x10-6 | ||
| hydrometra | 1 supporting dataset | Gp1bbtm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| increased mean platelet volume | 1 supporting dataset | Gp1bbtm1.1(KOMP)Vlcg | homozygote | Early adult | 1.02x10-21 | ||
| abnormal testis morphology | 1 supporting dataset | Gp1bbtm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| small testis | 1 supporting dataset | Gp1bbtm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/1) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
Human diseases caused by Gp1bb mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Gp1bb.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.