Tubb4a | tubulin, beta 4A class IVA
Physiological systems
18 / 24 physiological systems tested
1 Significantly impacted by the knock-out
Homeostasis/metabolism
17 No significant impact
6 Not tested
Data collections
Gene metrics:1Significant phenotypes
4Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues
| decreased fasting circulating glucose level | 1 supporting dataset | Tubb4atm1.1(KOMP)Wtsi | homozygote | Early adult | 3.2x10-7 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Tubb4a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tubb4a.
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| Tubb4atm1(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell mouse |
| Tubb4atm1.1(KOMP)Wtsi | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Tubb4atm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Tubb4atm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Tubb4atm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Tubb4atm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |