Ifng | interferon gamma
Physiological systems
20 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Nervous system Respiratory system Hematopoietic system Mortality/aging
16 No significant impact
4 Not tested
Data collections
Gene metrics:6Significant phenotypes
8Associated diseases
Expression examined in:73Adult tissues
29Embryo tissues
| abnormal lung morphology | 1 supporting dataset | Ifngtm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * | ||
| decreased prepulse inhibition | 2 supporting datasets | Ifngtm1.1(KOMP)Vlcg | heterozygote | Early adult | 4.59x10-9 | ||
| increased hematocrit | 1 supporting dataset | Ifngtm1.1(KOMP)Vlcg | heterozygote | Early adult | 4.83x10-5 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Ifngtm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Ifngtm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Ifngtm1.1(KOMP)Vlcg | homozygote | E12.5 | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 50% (1/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/1) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | n/a | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
Human diseases caused by Ifng mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ifng.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Ifngtm1(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Ifngtm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Ifngtm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Ifngtm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ifngtm2(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |