Ube2e1 | ubiquitin-conjugating enzyme E2E 1
Physiological systems
18 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Immune system Vision/eye Hematopoietic system
15 No significant impact
6 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased mean platelet volume | 1 supporting dataset | Ube2e1em1(IMPC)Marc | homozygote | Early adult | 2.23x10-5 | ||
| increased hematocrit | 1 supporting dataset | Ube2e1em1(IMPC)Marc | homozygote | Early adult | 1.59x10-14 | ||
| increased mean corpuscular volume | 1 supporting dataset | Ube2e1em1(IMPC)Marc | homozygote | Early adult | 5.75x10-35 | ||
| increased monocyte cell number | 1 supporting dataset | Ube2e1em1(IMPC)Marc | homozygote | Early adult | 5.42x10-8 | ||
| decreased mean corpuscular hemoglobin concentration | 1 supporting dataset | Ube2e1em1(IMPC)Marc | homozygote | Early adult | 4.88x10-35 | ||
| abnormal retina morphology | 1 supporting dataset | Ube2e1em1(IMPC)Marc | homozygote | Early adult | 2.47x10-6 |
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Human diseases caused by Ube2e1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ube2e1.
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| Ube2e1em1(IMPC)Marc | Deletion | | mouse |
| Ube2e1tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ube2e1tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |