Dnm1 | dynamin 1
Physiological systems
20 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Embryo Nervous system Mortality/aging Cardiovascular system
16 No significant impact
4 Not tested
Gene metrics:3Significant phenotypes
4Associated diseases
Expression examined in:73Adult tissues
104Embryo tissues
| hemorrhage | 1 supporting dataset | Dnm1tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| spina bifida | 1 supporting dataset | Dnm1tm1.1(KOMP)Vlcg | heterozygote | E15.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Dnm1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| hemorrhage | 1 supporting dataset | Dnm1tm1.1(KOMP)Vlcg | heterozygote | E15.5 | N/A * | ||
| spina bifida | 1 supporting dataset | Dnm1tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
Human diseases caused by Dnm1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Dnm1.
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| Dnm1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Dnm1tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Dnm1tm51066(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |