Tcea2 | transcription elongation factor A (SII), 2
Physiological systems
17 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Immune system Pigmentation Integument Hematopoietic system Cardiovascular system
12 No significant impact
7 Not tested
Data collections
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal coat/hair pigmentation | 1 supporting dataset | Tcea2em1(IMPC)J | homozygote | Early adult | 6.05x10-5 | ||
| prolonged QRS complex duration | 1 supporting dataset | Tcea2em1(IMPC)J | homozygote | Early adult | 1.04x10-5 | ||
| decreased leukocyte cell number | 1 supporting dataset | Tcea2em1(IMPC)J | homozygote | Early adult | 2.62x10-6 |
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Human diseases caused by Tcea2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tcea2.
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| Tcea2em1(IMPC)J | Exon Deletion | | mouse |
| Tcea2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Tcea2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |