Nsun2 | NOL1/NOP2/Sun domain family member 2
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Growth/size/body region Limbs/digits/tail Vision/eye Behavior/neurological Skeleton Craniofacial Mortality/aging
13 No significant impact
4 Not tested
Data collections
Gene metrics:16Significant phenotypes
3Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| abnormal joint morphology | 1 supporting dataset | Nsun2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 5.18x10-5 | ||
| abnormal gait | 1 supporting dataset | Nsun2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 7.94x10-5 | ||
| abnormal humerus morphology | 1 supporting dataset | Nsun2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 3.08x10-5 | ||
| abnormal response to new environment | 1 supporting dataset | Nsun2tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 1.08x10-5 | ||
| decreased body weight | 3 supporting datasets | Nsun2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 0 | ||
| abnormal cranium morphology | 1 supporting dataset | Nsun2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 6.13x10-6 | ||
| abnormal gait | 1 supporting dataset | Nsun2tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 6.53x10-5 | ||
| abnormal snout morphology | 1 supporting dataset | Nsun2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 3.37x10-5 | ||
| abnormal eye size | 1 supporting dataset | Nsun2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 6.11x10-5 | ||
| abnormal tooth morphology | 1 supporting dataset | Nsun2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 6.39x10-5 |
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| adrenal gland | heterozygote | n/a | 83.33% (5/6) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/6) | 0% (0/173) |
| bone | heterozygote | n/a | 100% (5/5) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (6/6) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/5) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 83.33% (5/6) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Nsun2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Nsun2.
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| Nsun2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Nsun2tm1c(EUCOMM)Wtsi | Wild type floxed exon (post-Flp) | | mouse |
| Nsun2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Nsun2tm42933(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |