Hmx3 | H6 homeobox 3
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Digestive/alimentary Nervous system Behavior/neurological
14 No significant impact
5 Not tested
Data collections
Viability data
Body weight measurements
Embryo imaging data
Body weight measurements
Embryo imaging data
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased grip strength | 3 supporting datasets | Hmx3tm1Ebo | homozygote | Early adult | 1.21x10-5 | ||
| abnormal locomotor activation | 1 supporting dataset | Hmx3tm1Ebo | homozygote | Early adult | 4.21x10-5 | ||
| decreased body weight | 1 supporting dataset | Hmx3tm1Ebo | homozygote | Early adult | 1.52x10-21 | ||
| hyperactivity | 1 supporting dataset | Hmx3tm1Ebo | homozygote | Early adult | 5.26x10-5 | ||
| abnormal gait | 1 supporting dataset | Hmx3tm1Ebo | homozygote | Early adult | 4.11x10-5 | ||
| abnormal defecation | 1 supporting dataset | Hmx3tm1Ebo | homozygote | Early adult | 2.49x10-5 | ||
| decreased prepulse inhibition | 1 supporting dataset | Hmx3tm1Ebo | homozygote | Early adult | 1.48x10-5 | ||
| decreased circulating triglyceride level | 1 supporting dataset | Hmx3tm1Ebo | homozygote | Early adult | 7.31x10-7 | ||
| abnormal behavior | 1 supporting dataset | Hmx3tm1Ebo | homozygote | Early adult | 8.97x10-5 | ||
| decreased circulating free fatty acids level | 1 supporting dataset | Hmx3tm1Ebo | homozygote | Early adult | 1.95x10-5 |
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Human diseases caused by Hmx3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Hmx3.
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| Hmx3tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Hmx3tm97282(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |