Gpld1 | glycosylphosphatidylinositol specific phospholipase D1
Physiological systems
21 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Adipose tissue Growth/size/body region Nervous system Hematopoietic system Cardiovascular system Mortality/aging Renal/urinary system
10 No significant impact
3 Not tested
Data collections
Gene metrics:15Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| small testis | 1 supporting dataset | Gpld1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| abnormal kidney morphology | 1 supporting dataset | Gpld1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| abnormal heart morphology | 1 supporting dataset | Gpld1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| increased heart weight | 2 supporting datasets | Gpld1tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.82x10-8 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Gpld1tm1.1(KOMP)Vlcg | homozygote | Early adult | 8.21x10-39 | ||
| enlarged heart | 1 supporting dataset | Gpld1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| increased lean body mass | 2 supporting datasets | Gpld1tm1.1(KOMP)Vlcg | homozygote | Early adult | 4.29x10-7 | ||
| increased brain weight | 1 supporting dataset | Gpld1tm1.1(KOMP)Vlcg | homozygote | Early adult | 4.71x10-5 | ||
| increased spleen weight | 1 supporting dataset | Gpld1tm1.1(KOMP)Vlcg | homozygote | Early adult | 6.11x10-5 | ||
| enlarged kidney | 1 supporting dataset | Gpld1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/1) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 50% (1/2) | 0.56% (3/532) |
Human diseases caused by Gpld1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Gpld1.
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| Gpld1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Gpld1tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Gpld1tm299268(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Gpld1tm38869(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |