Mbd6 | methyl-CpG binding domain protein 6
Physiological systems
23 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Digestive/alimentary Nervous system Cardiovascular system Mortality/aging Craniofacial Renal/urinary system
14 No significant impact
1 Not tested
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
84Embryo tissues
| cleft palate | 1 supporting dataset | Mbd6tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| increased kidney weight | 2 supporting datasets | Mbd6tm1.1(KOMP)Vlcg | heterozygote | Early adult | 2.6x10-7 | ||
| spina bifida | 1 supporting dataset | Mbd6tm1.1(KOMP)Vlcg | heterozygote | E15.5 | N/A * | ||
| hemorrhage | 1 supporting dataset | Mbd6tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| abnormal craniofacial morphology | 1 supporting dataset | Mbd6tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| hemorrhage | 1 supporting dataset | Mbd6tm1.1(KOMP)Vlcg | heterozygote | E15.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Mbd6tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| decreased body length | 1 supporting dataset | Mbd6tm1.1(KOMP)Vlcg | heterozygote | Early adult | 5.54x10-9 | ||
| spina bifida | 1 supporting dataset | Mbd6tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| edema | 1 supporting dataset | Mbd6tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * |
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| adrenal gland | heterozygote | Section images | 50% (1/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 50% (1/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | Section images | 50% (1/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 50% (1/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Section images | 100% (2/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
Human diseases caused by Mbd6 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mbd6.
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| Mbd6tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Mbd6tm1(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Mbd6tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Mbd6tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |